Humans aren’t exactly on the top of the food chain in Squanch Games’ High on Life 2. This first-person shooter takes place in a universe where aliens came to Earth to use humanity as ingredients for intergalactic pharmaceutical drugs. Now, a new trailer for the game facetiously markets itself to alien consumers as it encourages them to use Humanzapro, a new wonder drug made from humans.
The trailer is done in the style of pharmaceutical ads that typically run on American TV. All of the tropes of those ads are present, including the footage of happy aliens after they’ve taken the drug. Intriguingly, the ad warns humans that they shouldn’t be taking Humanzapro because of side effects. That makes us wonder if this particular drug will be a power-up during the game.
High on Life introduced players to the Rick and Morty-esque talkative sci-fi weapons, which was fitting since the first game was produced by Rick and Morty co-creator–and Squanch Games co-founder–Justin Roiland, who also voiced a sentient alien weapon. Roiland was forced out of Squanch Games and Rick and Morty following a series of allegations.
The sequel is introducing a new feature that will let players skateboard into battle and incorporate it into their offensive moves. Alternatively, players can use the boards to perform tricks.
High on Life 2 will hit PlayStation 5, Xbox Series X|S, and PC on February 13, 2026. It’s also slated to be a day-one Game Pass Ultimate release for PC and Xbox Series X|S. Outside of the game, it was reported that a High on Life animated series is in development.
